GN/INFLAMMATION

Epigenetic factors in acquired glomerular disease

Identify role of environmental exposures, i.e., viruses, toxins, and effect on dysregulation of the epigenome in the development of glomerular diseases without genetic mutations.

Characterize an individual's genetic propensity for adverse epigenomic changes.

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Idea#130

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  1. Comment
    Rama Natarajan

    It is clearly worth examining the role of epigenetic factors in CKDs especially in patients who develop CKDs like diabetic nephropathy even when they have reasonable glycemic control. This can tell us why genetic mutations do not always correspond to disease phenotype. Epigenetics can provide a key molecular link between genes and the environment

  2. Comment
    Karol Bomsztyk

    Epigenetics of disease is an emerging field with potential to provide powerful tools to diagnose (biomarkers) prevent and treat disease. Most progress in this area has been made in cancer where biomarkers are proving to be clinically useful and already epigenetic therapy is used to treat lymphomas. Although the use of epigenetic therapy to treat disease has just merely began and it has already provided the proof-of-concept for its application. Thus, combined application of genetics and epigenetics will undoubtedly be important in personalized medicine.

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