Mechanisms of repair and regeneration in acute kidney injury

Idea#222

Stage: Active

Campaign: AKI

This is an important area for mechanistic insights to further elucidate understanding of how the kidney elicits repair and regenerative processes in response to injury.

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16 votes

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Similar Ideas [ 4 ]

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Comments

  1. Comment
    Benjamin Lee

    We need better methods and assays to quantitate acute renal injury to help assess damage to the kidney.

  2. Comment
    Bruce Molitoris
    ( Moderator )

    Having methods to rapidly quantify function such as GFR or RBF or tubular function, would allow for establishing the severity of injury and extent of recovery with acute or chronic therapy.

  3. Comment
    Mark Okusa

    It would be best with methods that are noninvasive and provide information in real time. Contrast enhanced ultrasound is one tool that might be more effectively used.

  4. Comment
    Vinod BAnsal

    I agree with Dr Lee's comment that is we do need better methods to assess true renal injury as opposed to transient hypo perfusion.The severity of renal injury needs to be more quantitative something like burn injury. That would help to better understanding of mechanism of regeneration and subsequent the extent of renal recovery in terms of function.

  5. Comment
    James Tumlin

    I agree with Bruce and Mark's comments, but would like to add that we ultimately need a system of organized trialist to apply these approaches to the bedside. I fear nephrology is sorely behind in this area and getting worse. I also believe that if we were to reduplicate the sucess of the the ARDSnetwork in AKI, it would lead to more funding in this area. My two cents. J. Tumlin

  6. Comment
    Rick Schnellmann

    I agree with Anupam in that more effort should be devoted to the repair and regenerative processes following AKI and that drug-able targets may be in this area.

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