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Mechanisms of repair and regeneration in acute kidney injury

This is an important area for mechanistic insights to further elucidate understanding of how the kidney elicits repair and regenerative processes in response to injury.


Submitted by 3 years ago

Comments (6)

  1. We need better methods and assays to quantitate acute renal injury to help assess damage to the kidney.

    3 years ago
  2. Moderator

    Having methods to rapidly quantify function such as GFR or RBF or tubular function, would allow for establishing the severity of injury and extent of recovery with acute or chronic therapy.

    3 years ago
  3. It would be best with methods that are noninvasive and provide information in real time. Contrast enhanced ultrasound is one tool that might be more effectively used.

    3 years ago
  4. I agree with Dr Lee's comment that is we do need better methods to assess true renal injury as opposed to transient hypo perfusion.The severity of renal injury needs to be more quantitative something like burn injury. That would help to better understanding of mechanism of regeneration and subsequent the extent of renal recovery in terms of function.

    3 years ago
  5. I agree with Bruce and Mark's comments, but would like to add that we ultimately need a system of organized trialist to apply these approaches to the bedside. I fear nephrology is sorely behind in this area and getting worse. I also believe that if we were to reduplicate the sucess of the the ARDSnetwork in AKI, it would lead to more funding in this area. My two cents. J. Tumlin

    3 years ago
  6. I agree with Anupam in that more effort should be devoted to the repair and regenerative processes following AKI and that drug-able targets may be in this area.

    3 years ago

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