Obesity and CKD

Idea#108

Stage: Active

Campaign: CKD

The mechanisms by which obesity and metabolic syndrome influence kidney function has not been well elucidated. Studies to investigate potential pathways are needed

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  1. Comment
    Karen Moulton

    Is insulin resistance an underlying mechanism for endothelial dysfunction in the kidney and other microcirculatory beds?

  2. Comment
    Srini Beddhu

    I agree. The prevalence of obesity has substantially increased in the past decade. There are likely non-diabetes and non-hypertension mediated mechanisms of kidney injury in obesity. Interventional studies that target these mechanisms are warranted.

  3. Comment
    Andrew Rule

    A lot might be learned from studying the implantation biopsies of living kidney donors. Obesity is not uncommon in this population.

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