Browse Ideas with tag 'edema':

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  NORMAL BIOLOGY/DEVELOPMENT »

  Renal insensitivity to natriuretic peptides

  Cardiac natriuretic peptide ANP is thought to be the humoral factor connecting the heart function to the kidney and controlling the plasma volume-electrolyte balance. Yet, there are certain (patho)physiologic conditions where natriuretic response to ANP is severely blunted (e.g. in congestive heart failure). This apparent renal insensitivity to ANP - or "natriuretic peptide-escape" - is known to occur independent of the ...more »

  Cardiac natriuretic peptide ANP is thought to be the humoral factor connecting the heart function to the kidney and controlling the plasma volume-electrolyte balance. Yet, there are certain (patho)physiologic conditions where natriuretic response to ANP is severely blunted (e.g. in congestive heart failure). This apparent renal insensitivity to ANP - or "natriuretic peptide-escape" - is known to occur independent of the renin-angiotensin-aldosterone and sympathetic systems, and not due to receptor down-regulation. What is then the mechanism responsible? Can the mechanism be circumvented or modulated to effect natriuresis and reduction of the plasma volume? Since relieving edema is one most desired therapeutic outcome, it appears essential to address these questions.

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  Submitted by Kunio Misono 2 years ago

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  Rapid Fluid Retention Syndrome (RFRS)

  In our nephrology practice we see many patients with rapid fluid retention syndrome. We need to find the cause(s) of this "new syndrome".

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  Submitted by Sinasi Salman 2 years ago

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  AKI »

  What is the optimum serum Na level for AKI patients on CRRT?

  The acceptable serum Na level for ICU patients with AKI ranges from 133-148 mM. Administration of low Na fluids tends to keep serum Na ~135, whereas a higher serum Na of ~ 145 may help mobilize interstitial fluid and help lung compliance. An RCT is proposed for patients receiving CRRT where attempts would be made to keep serum Na close to either 136 vs. 144 mM, with the hypothesis that edema mobilization and lung compliance ...more »

  The acceptable serum Na level for ICU patients with AKI ranges from 133-148 mM. Administration of low Na fluids tends to keep serum Na ~135, whereas a higher serum Na of ~ 145 may help mobilize interstitial fluid and help lung compliance. An RCT is proposed for patients receiving CRRT where attempts would be made to keep serum Na close to either 136 vs. 144 mM, with the hypothesis that edema mobilization and lung compliance would be enhanced at the higher serum Na level.

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  Submitted by John Daugirdas 2 years ago

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