Browse Ideas with tag 'podocyte':

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  DIABETIC NEPHROPATHY »

  Can stem cells repair and reverse DN?

  Normally, metabolic and ischemic insults stimulate repair and regeneration. In diabetes, however, these processes are impaired. Recent advances in cell reprogramming hold great promise for future cell replacement therapies. How are specific populations of stem/progenitor cells affected by diabetes? Are these abnormalities reversible through optimal diabetes treatment or therapies targeted to stem/progenitor cells? ...more »

  Normally, metabolic and ischemic insults stimulate repair and regeneration. In diabetes, however, these processes are impaired. Recent advances in cell reprogramming hold great promise for future cell replacement therapies. How are specific populations of stem/progenitor cells affected by diabetes? Are these abnormalities reversible through optimal diabetes treatment or therapies targeted to stem/progenitor cells? Will new cell reprogramming techniques, such as induced pluripotent stem (iPS) cells, lead to individualized cell therapy? A barrier to understanding the impairments includes the known heterogeneity within stem cell compartments, specifically mesenchymal stem cells. Protocols are needed for the culture of progenitor cells and their thorough analysis, including genetic, epigenetic, and transcription factor analysis of individual cells and stem cell populations. Can ex vivo therapies be developed that reverse stem cell dysfunctions? Though iPS cells created with current protocols are unlikely to be transferred to people for treatment, these protocols offer the opportunity to take cells from individuals and direct their differentiation into cell-based models of DN.

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  Submitted by KUH Moderator 1 year ago

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  DIABETIC NEPHROPATHY »

  How does diabetes affect regeneration and repair?

  Tissue injury in diabetes results from cell damage and death, impaired communication among cells, dysfunction of nerves and blood vessels, and detrimental responses to systemic signals, such as inflammation. The development of the clinical manifestations depends on tissue-specific responses to injury and impairments in repair and regenerative processes. The knowledge base of the pathologic process in different tissues ...more »

  Tissue injury in diabetes results from cell damage and death, impaired communication among cells, dysfunction of nerves and blood vessels, and detrimental responses to systemic signals, such as inflammation. The development of the clinical manifestations depends on tissue-specific responses to injury and impairments in repair and regenerative processes. The knowledge base of the pathologic process in different tissues varies considerably, but in all organ systems a better understanding of the mechanisms is needed. How does systemic inflammation from dysregulation of the innate and adaptive immune systems affect the kidney? What are the mechanisms of injury in specialized cells, such as podocytes or tubular epithelial cells? What kidney disease is associated with diabetes from non-diabetes related forms of these diseases? Does diabetes accelerate the same pathologic processes or have unique components? What mechanisms are responsible for the increased mortality in people with diabetes and end-stage renal failure? Will aggressive treatment to normalize the blood sugar prevent this progression? Is there a point in the progression of diabetes complications when the pathologic process becomes relatively independent of the diabetes-related factors that initiate it? Is there a point when the progression becomes irreversible?

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  Submitted by KUH Moderator 1 year ago

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  DIABETIC NEPHROPATHY »

  Diabetic Nephropathy-abnormal vascular basement membrane

  What are the regulators of glomerular basement membranes? Can we target glomerular endothelium and podocytes to restore normal barrier components and functions?

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  Submitted by Karen Moulton 2 years ago

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  GN/INFLAMMATION »

  What is the molecular clock that orchestrates podocyte developme

  Podocyte plasticity is a feature of proteinuric glomerular diseases–sometimes reversible other times not. This may represent a reversal of the podocyte developmental process elegantly described by Reeves, Caulfield and Farquhar in 1978. The sequence of changes in morphology and protein expression that the developing podocyte manifests as it evolves from a simple cuboidal cell with a subapical tight junction to a highly ...more »

  Podocyte plasticity is a feature of proteinuric glomerular diseases–sometimes reversible other times not. This may represent a reversal of the podocyte developmental process elegantly described by Reeves, Caulfield and Farquhar in 1978. The sequence of changes in morphology and protein expression that the developing podocyte manifests as it evolves from a simple cuboidal cell with a subapical tight junction to a highly differentiated arborizing cell with slit diaphragm are now well established; however the molecular clock, genes and transcription factors that orchestrate this process have not been studied. This, in my opinion, is the next frontier in podocyte cell biology.

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  Submitted by David Salant 2 years ago

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