We don't see BKV Nephropathy as much in HIV patients on HAART therapy. Or to our knowledge it has been widely studied. This might be important in transplant world as perhaps BKV is suppressed by one of the HAART medications and a potential drug target for BK Nephropathy. We must look at other places besides Kidney Transplant for BKV Nephropathy for understanding the disease better perhaps.
First of all I'm only trying to stimulate thoughtful, well meaning and useful dialogue and not start a controversial argument, but is it time for the government to get more aggressive in making more organs available for transplantation? I think one thing that is missing is a general lack of public awareness or central discussion about the need for all organs. I know where I live in rural America it seems like renal transplantation ...more »
First of all I'm only trying to stimulate thoughtful, well meaning and useful dialogue and not start a controversial argument, but is it time for the government to get more aggressive in making more organs available for transplantation? I think one thing that is missing is a general lack of public awareness or central discussion about the need for all organs. I know where I live in rural America it seems like renal transplantation is very slow to occur and kidney-pancreas, heart and liver is generally non existence. Would a government sponsored increase in public awareness make much of a difference or do Americans just generally want to keep their organs even after they have expired for religious or other reasons? Should patients who have used tax payer funding for their health care be "forced" to give up their organs if the deceased patient would be buried with viable and badly needed organs? Again this is something that I have long thought about but never heard discussed and I can honestly say that I haven't formed a solid opinion on this. But again please limit any feedback to thoughtful and well meaning dialogue and keep our emotions in check.
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To improve the health outcomes of adolescents and emerging adults with CKD/ESKD as they transfer to adult-focused providers, a successful health care transition (HCT) process needs to take place. This preparation from parent-directed care to disease self management should be planned and monitored longitudinally. Tools to measure and monitor the HCT process need to be developed and validated.
This is an audacious objective, but would certainly win a Nobel Prize. Several submitted ideas are intermediates to this objective. The idea would be to develop a set of intermediate objectives to help achieve this big one.
Nakauchi recently described a method for making replacement organs using interspecies chimeras. When combined with the Yamanaka method for making stem cells this opens the door for the production of autologous organs. Many challenges remain. Not just the specific organ, but the vasculature and hematopoietic system might also need to be strictly patient derived. Could genetically engineered pigs work, or would we need ...more »
Nakauchi recently described a method for making replacement organs using interspecies chimeras. When combined with the Yamanaka method for making stem cells this opens the door for the production of autologous organs. Many challenges remain. Not just the specific organ, but the vasculature and hematopoietic system might also need to be strictly patient derived. Could genetically engineered pigs work, or would we need to go to a more closely related species? Cell. 2010 Sep 3;142(5):787-99.
Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.
Kobayashi T, Yamaguchi T, Hamanaka S, Kato-Itoh M, Yamazaki Y, Ibata M, Sato H, Lee YS, Usui J, Knisely AS, Hirabayashi M, Nakauchi H.
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