Browse Ideas with tag 'diabetic nephropathy':

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  NKDEP-Translation »

  Multifactorial intervention to stop progressive CKD

  Patients with progressive CKD (diabetic and non-diabetic) benefit from aggressive treatment that improves control of its antecedents, such as poor control of blood pressure, blood glucose, lipid profiles, etc. Some multifactorial interventions have been effective (most notably, the Steno2 Study) but none have been widely translated to populations or conducted in a diverse US population. Telehealth approaches may help ...more »

  Patients with progressive CKD (diabetic and non-diabetic) benefit from aggressive treatment that improves control of its antecedents, such as poor control of blood pressure, blood glucose, lipid profiles, etc. Some multifactorial interventions have been effective (most notably, the Steno2 Study) but none have been widely translated to populations or conducted in a diverse US population. Telehealth approaches may help overcome barriers to implementing efficacy studies in the US while allowing a scalable solution for translation to large populations (T2) if results are favorable.

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  Submitted by Uptal Patel 2 years ago

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  DIABETIC NEPHROPATHY »

  Large scale collection of CKD patient samples from dialysis unit

  Identifying robust association between genetic variation and severe human CKD phenotypes has been hindered by lack of collections of patient sample collection of sufficient size to use effectively in GWAS. The community could address this issue by developing reproducible but simple clinical phenotyping criteria and collecting samples from ESRD patients in dialysis units. Contrast can be made to publicly available datasets ...more »

  Identifying robust association between genetic variation and severe human CKD phenotypes has been hindered by lack of collections of patient sample collection of sufficient size to use effectively in GWAS. The community could address this issue by developing reproducible but simple clinical phenotyping criteria and collecting samples from ESRD patients in dialysis units. Contrast can be made to publicly available datasets of healthy volunteers with GWAS data. I am assuming, for example, that patients with diabetic nephropathy can be compared to healthy non-diabetic patients since the genetic architecture of type 2 diabetes common variants has been characterized.

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  3 comments for Idea: Large scale collection of CKD patient samples from dialysis unit

  Submitted by John Sedor 2 years ago

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  GN/INFLAMMATION »

  Glomerular biomarkers based on podocyte products

  Podocyte injury and depletion drive glomerulosclerosis and progression in glomerular diseases. The podocyte is on the urinary space side of the GBM so that urine is the logical place to look for markers of podocyte injury and the urine pellet is well known to contain valuable information. Several investigators have demonstrated that podocytes and their products can be detected in urine and are altered in a major way in ...more »

  Podocyte injury and depletion drive glomerulosclerosis and progression in glomerular diseases. The podocyte is on the urinary space side of the GBM so that urine is the logical place to look for markers of podocyte injury and the urine pellet is well known to contain valuable information. Several investigators have demonstrated that podocytes and their products can be detected in urine and are altered in a major way in association with progression in model systems and in man. Development and validation of biomarkers is a complex process that NIDDK has experience with for AKI. It is time to bring together groups working on glomerular disease urine biomarkers and define how they should be evaluated and validated in the clinic. We can thereby accelerate introduction of potentially game-changing technology to our clinics that can reduce the costs/morbidity of ESKD.

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  Submitted by Roger Wiggins 2 years ago

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  DIABETIC NEPHROPATHY »

  Can biomarkers predict type 2 diabetic nephropathy?

  The value of currently available urine biomarkers that identify those at risk for diabetic nephropathy is increasingly called into question. The development of new urine and plasma biomarkers to predict diabetic nephropathy may shed light on disease mechanisms. Also, rational clinical trial design will be made possible by such markers.

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  Submitted by Jon Klein 2 years ago

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  NORMAL BIOLOGY/DEVELOPMENT »

  Mouse Tool Development

  Do we need a set of validated tools for mouse models of kidney disease (and development), available to all, for example Cre/CreER drivers for the major relevant differentiated cell types in adult kidney (endothelial, nephron epithelia by segment, fibroblast, macrophage etc...)?

  3 comments for Idea: Mouse Tool Development

  Submitted by Ben Humphreys 2 years ago

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