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  Targeting phosphate metabolism in CKD to improve survival

  Disordered phosphate metabolism is associated with increased risk of death in ESRD, CKD, following kidney transplantation, and in the general population. FGF23 is an early marker of disordered phosphate metabolism that could be used to identify participants for an RCT in which one or a combination of phosphate binders, dietary manipulation or niacin could be used versus placebo to examine impact on CKD progression and ...more »

  Disordered phosphate metabolism is associated with increased risk of death in ESRD, CKD, following kidney transplantation, and in the general population. FGF23 is an early marker of disordered phosphate metabolism that could be used to identify participants for an RCT in which one or a combination of phosphate binders, dietary manipulation or niacin could be used versus placebo to examine impact on CKD progression and mortality.

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  Submitted by M Wolf 2 years ago

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  Endocrine regulation of mineral ion metabolism

  Study endocrine (bone-kidney axis) regulation of calcium and phosphate metabolism by FGF23-klotho system. Explore how FGF23-klotho system influences PTH and vitamin D in CKD to induce phosphate toxicity and associated complications, including vascular calcification.

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  Submitted by Mohammed Razzaque 2 years ago

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