Browse Ideas with tag 'stem cells':

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  NORMAL BIOLOGY/DEVELOPMENT »

  Development and Regeneration

  Before we can think about stem cells or iPS cell based therapies, we need to understand how renal epithelial cells are programmed. Basic studies in development and differentiation will help to identify factors that could be used for reprogramming. We may find that it is easier to reprogram a renal fibroblast or myofibroblast into an epithelial cell if we introduce the right combination of factors. These ideas are being ...more »

  Before we can think about stem cells or iPS cell based therapies, we need to understand how renal epithelial cells are programmed. Basic studies in development and differentiation will help to identify factors that could be used for reprogramming. We may find that it is easier to reprogram a renal fibroblast or myofibroblast into an epithelial cell if we introduce the right combination of factors. These ideas are being pursued in the pancreas and other tissues. Pushing forward with stem cell based therapies without a basic understanding of development is potentially dangerous. Of course this is a biased view from a basic scientist.

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  5 comments for Idea: Development and Regeneration

  Submitted by Greg Dressler 2 years ago

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  CKD »

  More Skepticism

  As a community, we need to be more critical of the science being done in our field. There is much confusion, debate, and disagreement when it comes to disease mechanisms in the kidney. Issues like whether EMT occurs or whether stem cells exist are not at all clear. Much of the prevailing views are based on scant evidence. We are doing a disservice to young PIs who may base their fledgling research programs on poorly ...more »

  As a community, we need to be more critical of the science being done in our field. There is much confusion, debate, and disagreement when it comes to disease mechanisms in the kidney. Issues like whether EMT occurs or whether stem cells exist are not at all clear. Much of the prevailing views are based on scant evidence. We are doing a disservice to young PIs who may base their fledgling research programs on poorly substantiated dogma.

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  4 comments for Idea: More Skepticism

  Submitted by Greg Dressler 2 years ago

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