Frederick Kaskel

Member since 2 years ago

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• Newbie

4 ideas posted

9 comments 16 votes

78 points View the Leaderboard

Years in Research or Practice?:

20+

What is your primary focus?:

Other

Degree:

MD, PhD

Affilliation:

Albert Einstein College of Medicine

Do you do research?:

Yes

Do you see patients?:

Yes

Are you a lay person?:

No

Work Zip Code:

10467

Frederick Kaskel is a member of:

• KIDNEY RESEARCH NATIONAL DIALOGUE-PHASE I

Activity Stream

Ideas contributed by Frederick Kaskel

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  NKDEP-Translation »

  NKDEP and Prevention of Risks for CKD in Pediatrics

  The epidemic of obesity in the pediatric population must be addressed using the resources available in translational research if we are to stem the onset of cardiovascular disease in this population. Educational initiatives set forth in the NKDEP are excellent starting points to extend into schools, communities, and other facilities aimed at identifying those at risk and facilitating appropriate guidance. Short- and ...more »

  The epidemic of obesity in the pediatric population must be addressed using the resources available in translational research if we are to stem the onset of cardiovascular disease in this population. Educational initiatives set forth in the NKDEP are excellent starting points to extend into schools, communities, and other facilities aimed at identifying those at risk and facilitating appropriate guidance. Short- and long-term outcome studies are needed to assess for novel approaches to this emerging public health crisis.

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  Submitted by Frederick Kaskel 2 years ago

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  4 votes

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  HYPERTENSION »

  Pediatric Hypertension and risk for cardiovascular disease

  The development of hypertension in the pediatric age group serves as a model for the investigation of the natural history, risk factors, and prevention of cardiovascular disease. There is a need for GWAS studies in populations at risk, i.e., African Americans, Latino Americans, and obese children and those with sustained high blood pressure. Utilize existing databases, CKiD and compare to normal populations during growth ...more »

  The development of hypertension in the pediatric age group serves as a model for the investigation of the natural history, risk factors, and prevention of cardiovascular disease. There is a need for GWAS studies in populations at risk, i.e., African Americans, Latino Americans, and obese children and those with sustained high blood pressure.

  Utilize existing databases, CKiD and compare to normal populations during growth and development.

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  Add your comment for Idea: Pediatric Hypertension and risk for cardiovascular disease

  Submitted by Frederick Kaskel 2 years ago

• I agree

  11 votes

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  GN/INFLAMMATION »

  Epigenetic factors in acquired glomerular disease

  Identify role of environmental exposures, i.e., viruses, toxins, and effect on dysregulation of the epigenome in the development of glomerular diseases without genetic mutations.

  Characterize an individual's genetic propensity for adverse epigenomic changes.

  2 comments for Idea: Epigenetic factors in acquired glomerular disease

  Submitted by Frederick Kaskel 2 years ago

• I agree

  11 votes

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  NORMAL BIOLOGY/DEVELOPMENT »

  Role of epigenetics in normal development and its dysregulation

  Investigate the role of epigenome disruptors that change gene activity and alter stem cell activity resulting in gene dysregulation. (Science 29 Oct 2010 330) “Epimutations” can pass through germ line to the gametes and affect heredity. Stem cells display developmental plasticity and offer opportunity to examine epigenetic peturbations during normal development such as DNA methylation as well as their response to injurious ...more »

  Investigate the role of epigenome disruptors that change gene activity and alter stem cell activity resulting in gene dysregulation. (Science 29 Oct 2010 330)

  “Epimutations” can pass through germ line to the gametes and affect heredity.

  Stem cells display developmental plasticity and offer opportunity to examine epigenetic peturbations during normal development such as DNA methylation as well as their response to injurious agents (epigenetic reprogramming?)

  Identify mechanisms responsible for the plasticity of epigenetic states that may be operative in dysregulation in disease.

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  Add your comment for Idea: Role of epigenetics in normal development and its dysregulation

  Submitted by Frederick Kaskel 2 years ago

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